Advanced Immunology (E05N3A)
- to have an insight in the immunological mechanisms which explain the pathogenesis of autoimmune diseases. - to provide an overview of the biological actions of cytokines and chemokines. - to understand the role of proteases and proteolysis in inflammatory diseases
Mode of examination
Oral exam with written preparation. (People who follow the Dutch master can make their exam in Dutch)
Opdenakker + Struyf: oral exam (resp. 2 and 1 question)
Vandamme + Wouters: written exam (both 1 question)
Matthys: presentation, based on an assigned article, 1 week preparation
Liston: presentation, based on an assigned article, prepared in class
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2012 - 2013
-Discuss the IL6 familiy: gene regulation, receptors, signaltransduction, biotests, target cells.
-Discuss CC-chemokines: gene regulation, production, structure, receptors, purification, biotests, target cells, modification antagonism, modification and role in diseases.
-Discuss Interferons: gene regulation, receptors, signaltransduction, production and purification, biotests, target cells, clinical applications.
-Discuss the IL-1 family: a) Agonists and antagonists: characteristics and mode of action b) Biological role in vitro and in vivo c) Different family members
-Discuss CXC-family a) Structure, characterisation, source-cells b) Biological activity: biotest, target cells, receptors c) Production, purification, modification, identification d) Role in disease, antagonism
-Discuss the process and function of O-glycosylation and the differences with N-glycosylation with examples from immunology.
-How would you develop a specific protease-inhibitor with a limited and an unlimited budget?
-Discuss the classes of the proteases. (added question: give the natural inhibitors)
-Discuss in 5 rules: epitope-scanning, AGEs, Tysabri, Trastuzumab, normal leukocytosis.
-If you want to inhibit a target-protease. How would you do it? Give a short explanation of the used techniques.
-Discus the role of sugars as Antigens in the development of the immune system, infections and autoimmune disorders.
-Give the immunopathology of MS in a scheme.
-Discuss the most important receptors in leukocytosis.
-Explain endotoxine-shock and compare with other acute infections.
-Discuss in 5 rules: epitope-scanning, 5 autoimmune diseases (Antigen, immunological mechanism, organ), TLR9
-Give the REGA-model and give intervention-points for an autoimmune disease.
-Discuss the immunological base and molecular mechanism of neutrophils in immunopathology. What treatment would you give?
-What is the function of glycosylation of IgG?
-Give the number of leukocytes in a 25-year old, healthy person in 5 different leukocyte-classes.
2013 - 2014
Discuss the structure and function of NOD2 and how this is involved in the pathogenesis of Blau Syndrome.
Discuss the IL-1 family: a) Ligands and receptors as agonists and antagonists b) Biological functions in vitro and in vivo c) Other members and receptors of the Ig superfamily
Discuss GCP-2 and PF-4var and receptors in cancer
Extra: make correct groups with words about cytokines and their receptors + Explain LAK-cells
- Explain how intracellular and extracellular proteolysis are involved in autoimmunity. Knowing this, how can it help in diagnosis and therapy of rheumatoid arthritis.
- Stucture and function of oligosaccharides in glcosylated immunological proteins.
2 main questions - each 5 points - give the 5 classes of proteases with examples, location and function - RA as autoimmune disease: development (REGA model, IL-8, MMP9, collagen), current treatment and oportunities (D-penicillamine)
a List of 10 terms you get if he reads the answers to the 2 main questions - each one point - SERPIN - give a molecules increasing leukocytosis - AGE - -