Advances in Neurobiology of Psychiatric Disorders (E00V5A)
Psychiatric disorders are clinical constructs based on symptom clusters. The underlying psychopathological dimensions such as mood changes, psychotic phenomena, anxiety, impulsivity or compulsivity can be linked to dysfunctions of specific brain circuits, which can be studied by brain imaging. Genetic polymorphisms and epigenetic changes have been shown to contribute to these psychopathological features. Animal models have been developed that show face, construct and predictive validity for specific psychiatric disorders. The course consist of three parts, each with specific aims, which logically build upon one another. In the first part, the student will get acquainted with psychiatric nosology and with relevant aspects of neuroanatomy and of developmental neurobiology. In the second part, animal models, brain imaging and genetics will be presented as three major methods to elucidate the neurobiology of psychiatric disorders. In the third part finally, the current state of knowledge of the neurobiology of psychosis, mood changes, autism, ADHD, anxiety and OCD will be presented.
written exam, closed book
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- Discuss the structure and function of the hippocampal formation.
- Discuss how the environment can influence the development of the central nervous system, give some examples.
- Which test can be performed to assess rodents' behaviour in shizophrenia? Give 3 concerns with regards to testing schizophreniform disorders in rodents.
- Describe the role of neuro-amines in neurobiology of depression
- What is the role of frontal cortex in social cognitive functioning?
- Explain abberant salience and dopamine in psychosis.
- Discuss the structure and function of the Amygdaloid body.
- Describe the diagnostic criteria for Panic Disorder and the associated neuroanatomical changes.
Peeters explain: ASD is a polygenic or multifactorial disease
- Explain dyslexia (with regards to phonological representations) and why are these in children possibly impaired while intact in adults?
- Explain the relation of dopamine and psychosis (with regards to salience).
- What is the role of mono-amines in depression?
- Explain the neurobiology of OCD.
- How can we diagnose Lewy Body Disease and frontotemporal lobe dementia with neuroimaging?
- Can early life events influence the stress-axis and via which underlying mechanism does this happen?
- Explain dopamine dysregulation (final common pathway)
- Explain dyslexia (with regards to phonological representations) and the debate about this hypothesis
- HPA-axis and depression