Advances in Oncology II (E09F8A)
Cancer develops when gradual irreversible genetic or epigenetic changes accumulate in a cell and transform the cellular proteome in a way that a malignant cellular phenotype can develop. Typical characteristics of the malignant cellular phenotype are: unrestricted and autonomous cell growth, unlimited cell proliferation, resistance to apoptosis, tissue invasion and induction of angiogenesis and genetic instability.
In ‘Advances in Oncology II’, important concepts of cell biology, experimental approaches and therapeutic principles of cancer are considered in detail, by means of a series of lectures given by several speakers (each talking about one concept and their research) and recent reviews in literature.
Mode of examination
Questions need to be solved written. If needed, additional questions are asked orally (when handing in).
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Summary of the most important basics needed for the Oncology II course; summary of senescence articles; some relevant extra information.
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Examenvragen '13 - '14
1) Give the different hallmarks of cancer
2) What happens in the NFkB pathway during cancer
1) p53 reactivation therapy: pharmacological means
Exam questions '14 - '15
1) Mechanisms that p53 gets activated after oncogenic stress and the possible outcomes for the cell
2) describe the CDKN2A locus -also what happens at cancer
3) describe the Tet system and what is it contribution to cancer development
1) Explain the concept 'addiction to loss of tumor suppressor function' and illustrate with an in vivo experiment.
2) Discuss how oncogene activation is involved in the RB pathway and how it can lead to irreversible cell cycle arrest.
3) How can 'epigenetics' contribute to diagnosis and therapy of cancer?