Model Systems in fundamental and clinical research (E05E4A)
The past twenty years we have seen an unprecedented growth in our knowledge of biological processes that underlie normal development, function and pathology. A combination of classical genetics, experimental embryology and molecular genetics in model sytems such as Drosophila, Xenopus, zebrafish, C. elegans, mouse and other, hereby led to important new insights into fundamental and often evolutionary conserved mechanisms. Examples of the importance of model systems are the Nobel Prizes in Medicine and Physiology, which were awarded in 1995 to Nüsslein-Volhard, Wieschaus and Lewis for their work on Drosophila and in 2002 to Horvitz, Sulston, and C. Brenner for work on C. elegans. The purpose of this course is that you become familiar with genetic model systems and the associated techniques. Moreover, you will understand the importance of such research to gain insights into complex biological phenomena. Finally you will learn about recent scientific breakthroughs. The course consists of a combination of lessons, analysis of scientific publications and lectures by prominent researchers. Of each model system you get a general introduction, followed by the relevant original scientific publication(s) and discussion of the fundamental and/or medical implications.
Paper: The filing of the take-home assignment is mandatory. The assignment has to be submitted, otherwise you can't pass for this course.
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